AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection

AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection.

Bacteria can change its lifestyle during inhabiting in host niches where they survive and replicate by rapidly altering gene expression pattern to accommodate the new environment. In this study, two novel regulators in avian pathogenic Escherichia coli (APEC) were identified and designated as AutA and AutR. RT-PCR and β-galactosidase assay results showed that AutA and AutR co-regulated the expr...

Thymus transcriptome reveals novel pathways in response to avian pathogenic Escherichia coli infection

Avian pathogenic Escherichia coli (APEC) can cause significant morbidity in chickens. The thymus provides the essential environment for T cell development; however, the thymus transcriptome has not been examined for gene expression in response to APEC infection. An improved understanding of the host genomic response to APEC infection could inform future breeding programs for disease resistance ...

papA gene of avian pathogenic Escherichia coli.

P fimbrial adhesins may be associated with the virulence of avian pathogenic Escherichia coli (APEC). However, most APECs are unable to express P fimbriae even when they are grown under conditions that favor P fimbrial expression. This failure can be explained by the complete absence of the pap operon or the presence of an incomplete pap operon in Pap-negative APEC strains. In the present study...

Identification and Purification of F11 Fimbriae on Avian Pathogenic Escherichia coli

Deciphering the infection biology of avian pathogenic Escherichia coli: role of experimental infection models

Avian pathogenic Escherichia coli (APEC) is a well-recognised pathotype that causes localised and systemic infections in avian species of all ages including eggs. To develop successful intervention strategies, a deep understanding of bacterial and host factors mediating crucial processes in pathogenesis is required. Such information can only be gathered through approaches that embrace infection...